Pulmonary complications continue after ILD single lung transplantation

Top line:

Including native lung complications after single lung transplantation (SLT) in patients with interstitial lung disease (ILD) pneumothorax,lung aspergillosisand acute exacerbation.

methodology:

• single-lung transplant It is often preferred in areas with donor shortages, but data regarding complications and changes over time are limited.
• Researchers reviewed data from 34 adult patients with ILD who underwent a single SLT at a single institution. Another 54 adults who underwent SLT for other conditions served as controls.
• Although the median age of patients in the ILD and non-ILD groups was similar (53 and 47 years, respectively), there were significantly more men in the ILD group (67.7% vs. 22.2%) and patients with a significantly higher BMI. (median 22.2 vs. 17.7).
• Patients were evaluated at three specific time points: pretransplant, 6 months posttransplant, and 2 years posttransplant.

remove:

• Overall, native lung volumes decreased over time with median values ​​of 1.134 L, 0.747 L, and 0.653 L at baseline, 6 months post-transplant, and 2 years post-transplant, respectively.
• In the ILD group, perfusion showed a decreasing trend over time. Radiographic changes were present but minimal.
• The top complications of residual native lung in patients with ILD included pneumothorax (29.4%), pulmonary aspergillosis (11.8%), and acute exacerbation (8.9%).
• Three-month mortality and long-term prognosis were similar between patients with and without ILD.

in fact:

“Our analysis together with previous reports suggests that ILD progresses slowly and continues to erode its structural and functional integrity after SLTx, and that high-dose immunization after SLTx “This supports the idea that spontaneous pulmonary fibrosis continues to worsen despite inhibitors,” the researchers wrote.

sauce:

The study's co-lead authors were Toshikazu Watanabe, MD, and Takashi Hirama, MD, of Tohoku University in Sendai, Miyagi Prefecture. The research is Published online April 24, 2024 BMC Respiratory Medicine.

Limitations:

Small sample size, use of data from a single institution, limited number of spontaneous lung events, and differential management of complications were factors that limited study results. .

Disclosure:

This research was supported by Grant-in-Aid for Scientific Research C from the Japan Society for the Promotion of Science, the Takeda Science Foundation (Visionary Research 2021), and the Life Science Research Institute of Tokyo Health Society Hospital. The researchers had no financial disputes to disclose.