Iron deficiency associated with kidney outcome in nondialysis-dependent CKD without anemia

Important takeouts:

• Overall, 27.2% of patients suffered from serum ferritin at <100 ng/ml.
• Additionally, this study found that 13.1% of patients had transferrin saturation levels below 20%.

Iron deficiency may be associated with nondialysis-dependent chronic kidney disease and mortality in patients without anemia, according to results from a national cohort study.

Iron is an important component of hemoglobin and myoglobin, butIron deficiency It is linked to many pathophysiological conditions such as anemia, heart failure, and cancer,” said the researcher. Hongxue Yu, Xian Shao and zhixin Guo, I wrote with a colleague at the Kidney Disease Department at Nanphun Hospital, China. ” Detection of iron deficiency Patients with no anemia need additional support from clinical evidence. However, existing studies focus on the effects of iron deficiency in anemia patients, with limited evidence regarding the outcome of iron deficiency in CKD patients without anemia. ”

The researchers conducted a multicenter retrospective study of data from 18,878 adults from 24 hospitals across China using identification data from the Chinese kidney data system from 2000 to 2022. The analysis investigated whether serum ferritin or transferrin saturation levels were associated with CKD progression and all course mortality. Outcomes in patients without anemia.

The total cohort had nondialysis-dependent CKD. 9,989 patients were included in kidney outcome analysis, and 18,481 patients were included in all-cause mortality analysis.

The findings showed that 27.2% of patients had serum ferritin at <100 ng/ml and 13.1% had transferrin saturation levels of <20%. Patients with transferrin saturation <20% had a higher risk of progression of kidney disease, as seen in the adjusted hazard ratio (AHR = 1.66; 95% CI, 1.16-2.37). Additionally, this group had a higher risk of all-cause mortality (AHR = 2.21; 95% CI, 1.36-3.57) and had a higher risk of transferrin saturation.

The researchers confirmed the results of subgroup analyses, but found no correlation between serum ferritin levels and the risk of CKD progression or death.

“Iron deficiency was prevalent [non-dialysis-dependent] “Anemia-free NDD-CKD patients, and translin saturation, may be modifiable risk factors for CKD progression and all-cause mortality,” the researchers wrote. “To improve patient outcome, we recommend that you include screening iron biomarkers, especially TSAT, at the early stages of NDD-CKD. Furthermore, time for renal outcomes and all-cause mortality in CKD patients. A well-designed randomized clinical trial is required to see the impact of Lee iron supplementation treatments.”

Published:

Add topics to email alerts

You will receive an email when a new article is posted

Please provide your email address to receive emails when new articles are posted .

“data-action = “subscribe”> subscribe

We were unable to process your request. Please try again later. Please contact us if you want to continue to maintain this issue customerservice@slackinc.com.

Return to Healio