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Home Kidney Transplantation Transplanted pig kidneys free her from eight years of dialysis

Transplanted pig kidneys free her from eight years of dialysis

by LAURAN NEERGAARD
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New York (AP) – Alabama woman recovers quite a while later Porcine kidney transplantation Last month, she released her from eight years of dialysis, and her latest efforts to save human lives with animal organs.

Towana Rooney is like that The fifth American I'll be given Gene-editing pig organs – In particular, she is not ill Previous recipients The one who died inside 2 months Receive pig kidneys and heart.

“It's like a new beginning,” Rooney, 53, told The Associated Press. Immediately, “The energy I had was amazing. Having working kidneys and feeling them is incredible.”


Pig kidney recipient Towana Looney will be visited by Dr. Transplant Surgeon at Nyu Langone Health in New York City. (AP photo/Shellby Rum)

Rooney's surgery tells us key steps as scientists prepare for a formal xenograft study, which is expected to begin next year, and Nyu, who led a highly experimental procedure on November 25th said Dr. Robert Montgomery of Langone Health.

On Tuesday, NYU announced that Rooney is recovering well. She was discharged from the hospital just 11 days after the surgery, but was temporarily re-adjusted this week to adjust her medication. Doctors hope she will return to Gadsden, Alabama in three months. If the pig's kidneys failed, she was able to start dialysis again.

“To see hope has recovered to her and her family,” said Dr. Jame Locke, former Rooney surgeon who secured Food and Drug Administration permission for the transplant.

Gene-edited pig kidneys will be removed from the package in the operating room of NYU Langone Health in New York on November 25, 2024 (Joe Carrotta of Nyu Langone Health via the AP)

Gene-edited pig kidneys will be removed from NYU Langone Health's operating room package on November 25, 2024 (Joe Carrotta of Nyu Langone Health via AP)

Transplant Surgeon Chrisilla Yang, Left, Robert Montgomery prepares patient Towana Looney to receive gene-edited pig kidneys at NYU Langone Health in New York on November 25, 2024.

Transplant Surgeons prepare patient Towana Looney to receive gene-edited pig kidneys at NYU Langone Health on November 25, 2024 (Joe Carrotta/Nyu Langone Health via AP)

Over 100,000 people are on the US transplant list, and most people need kidneys. Thousands of people will wait and die, and many who need a transplant are never eligible. Now, scientists are genetically altering pigs in search of alternative supplies, making organs more human.

Rooney donated his kidneys to his mother in 1999. The complications of pregnancy then caused hypertension, causing damage to the remaining kidneys, which ultimately failed. Although it is given further priority on the transplant list, it is very rare for a living donor to develop kidney failure.

However, Rooney couldn't get a match – she developed an unusually prepared antibody to attack another human kidney. Tests showed that she refused the rejection provided by all kidney donors.

After that, Rooney asked about pig kidney research at T. His University of Alabama Birmingham And to Rock, at the time of the UAB transplant surgeon, she wanted to give it a try. In April 2023, Locke filed an FDA application calling for an emergency experiment under rules for people like Rooney, who are out of the option.

The FDA immediately disagreed. Instead, the world's first gene-edited pig kidney transplant went to two sick patients at Massachusetts General Hospital and NYU last spring. Both had serious heart disease. The Boston patient recovered enough to spend about a month at home before dying from sudden cardiac arrest. A NYU patient suffered from cardiac complications that damaged the pig's kidneys and forced it to be removed, which later died.

These disappointing results did not discourage Rooney, who was beginning to get worse about dialysis, but Locke said he had no heart disease or other complications. The FDA eventually allowed the port at NYU, where Locke worked with Montgomery.

The moment Montgomery sewed the pig's kidneys into place it turned into a healthy pink and began to produce urine.

Even if her new organ fails, doctors can learn from it, Rooney told the AP:

Pig Kidney Recipient Towana Looney stands with the transplant surgeon. Dr. Jamelock, left, US Administration of Health Resources & Services, and Dr. Robert Montgomery of Nyu Langone Health, Nyu Langone Health, New York City, December 10, 2024. (AP photo/Shellby Rum)

Pig kidney recipient Towana Rooney has a transplant surgeon, Dr. Jame Locke, on the left, and Dr. Robert Montgomery, a center at New Langone Health. (AP photo/Shellby Rum)

Based in Blacksburg, Virginia, Revivicor has given Rooney's new kidneys from pigs with 10 genetic changes. Parent company United Therapeutics said Tuesday it plans to submit an application to the FDA “quickly.”

Rooney was first discharged from the hospital on December 6th, wearing a monitor to track blood pressure, heart rate and other physical functions, and returning to the hospital for daily examinations prior to readmission of medication. The doctor examined her blood work and other tests and compared them with previous studies of the animals. A few people Hopefully we'll discover an early warning if any issues arise.

“A lot of what we see, we're the first to see,” Montgomery said.

Lock, who recently joined the Federal Health Services Agency, visited last week to confirm patient progress over the years. Rooney hugged her and said, “Thank you for giving up on me.”

“Never,” Rock replied.

___

The Associated Press School of Health Sciences is supported by the Science and Education Media Group at Howard Hughes Medical Institutions. AP is solely responsible for all content.

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Welcome to Daily Transplant News, your trusted source for the latest updates, stories, and information on transplantation and organ donations. We are passionate about sharing the inspiring journeys, groundbreaking research, and invaluable resources surrounding the world of transplantation.

About Us

Welcome to Daily Transplant News, your trusted source for the latest updates, stories, and information on transplantation and organ donations. We are passionate about sharing the inspiring journeys, groundbreaking research, and invaluable resources surrounding the world of transplantation.

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